Tuesday, March 5, 2013

Nintendo to Show a Lot of Unreleased Games at the SXSW Gaming ...

@MasterWario I agree, Nintendo has a bit of a marketing problem at the moment. Though, I do feel like games don't get nearly as much advertising as movies in that you hardly see marketing for it until a week or so prior to release. I remember only seeing Dead Space 3 commercials not long before and after it released. Now, it is pretty much non-existent.

It doesn't help that pretty much every site has this weird bias against Nintendo (other than here....obviously). There are a few stories here that I haven't seen anywhere else. For instance....there were 2 indie games announced for the Wii U and 2 different devs gave Nintendo praise for how easy they are to work with....IGN had neither story, nor the one about Crysis 3 being ready to launch. Joystiq is a little better, but not much.

I kind of feel like Nintendo is doing a soft launch of the Wii U, since there were hardly any commercials around during launch and none of them really showed anything. Let the early adopters pick it up, help with tweaks, word of mouth, streamline and build the Miiverse while the library grows. Then blow the doors off at E3 and bring a deluge of games this fall.

I'd expect to see commercials/ads for Luigi's Mansion in the next couple weeks, same goes for Lego City....especially on channels with child demographics. Marketing to kids will get the parents to buy, while gamers tend to know about things ahead of time. Casuals might see an ad somewhere but neither of those games falls into the same market as something like Wii Fit, so they are less likely to care regardless.

Source: http://www.nintendolife.com/news/2013/03/nintendo_to_show_a_lot_of_unreleased_games_at_the_sxsw_gaming_expo

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Comparing iPhone calendar apps at a glance

Comparing iPhone calendar apps at a glance

I've compared the main screens of iPhone Twitter apps, weather apps, and podcast apps, and next on the agenda is calendar apps. While iOS contains a default calendar app, and many people find it affable enough, it never seemed to get as much high level Apple attention as some of the other core apps. Maybe that's why a plethora of canny developers and designers have managed to reverse-Sherlock (Moriarty?) Apple and put out good look, great working calendar apps that go above and beyond the default. For this piece, I'm taking a quick look at the standard view of 11 of them, including the built-in iOS Calendars app, for a total of 12.

Calendar apps, like other categories, tend to fall into two main categories: minimalist, which surfaces glance-able information and lets you dig more deeply when and as needed, and crammed, where all much data is shown on the screen at one time as is digitally possible. Some fall very much into the iPhone's design aesthetic, while others look almost purpose-built to make former Windows Mobile users feel at home, and yet other are almost Windows Phone Metro chic.

Here they are, in order:

iPhone calendar default screens

Of course, the default view is just that -- the default view. Almost all calendar apps let you switch between some combination of year, month, day, and list view, and many have special features beyond the views as well. For a more in-depth look, check out our full reviews.

However, since pictures, or in this case, screenshots, can be worth a thousand words, check out the designs above and let me know what you think. Which calendar apps do you use, and are they the same ones that appeal to you most in the comparison above? Any of the calendar screens attractive enough they encourage you check out an alternative app?



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/7NxCrtsy9RY/story01.htm

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The rise of WebKit browsers, and the fear of IE6-style stagnation

The rise of WebKit browsers, and the fear of IE6-style stagnation

Now that Opera has announced they'll be switching from their Presto HTML rendering engine to WebKit, the open source engine rendering engine Apple forked from KHTML, there's been some concern that having such a dominant technology could one again lead to the type of browser stagnation we suffered under Microsoft and Internet Explorer 6 (IE6). Indeed, Safari on iOS and OS X, Google's Chrome, Palm's webOS, BlackBerry's Torch, and others have all based themselves on WebKit. Writing on Hypercritical, however, John Siracusa thinks the parallel doesn't hold:

I haven?t forgotten the past. A single, crappy web browser coming to dominate the market would be just as terrible today as it was in the dark days of IE6. But WebKit is not a browser. Like Linux, it?s an enabling technology. Like Linux, it?s free, open-source, and therefore beyond the control of any single entity.

I think Siracuse's exactly right. IE was a proprietary app with an ActiveX lock-in. WebKit has become infrastructure surfaced in many apps. Too many, too smart companies all have stake in WebKit and driving it forward. It's open source, but can be strongly opinionated by platform.

It's the best of both browser worlds.

And if you hate it, you still have Microsoft's Spyglass and Mozilla's Gecko to keep you company, or as long as they can keep up.

Source: Hypercritical



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/wtRtVKZSNvU/story01.htm

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Monday, March 4, 2013

What Was The First Video Game Console Called?


Answer: Brown Box

The world?s first video game console system had an entirely uninspiring name?designers simply referred to it as the ?Brown Box?. The Brown Box was developed in 1967 by German engineer Ralph Baer and included control paddles and a light gun.

Baer and associates pitched the system to various electronics companies, eventually securing a contract with Magnavox. The Brown Box would undergo various revisions and improvements before release to the public as the Magnavox Odyssey in 1972.

Despite the public?s interest in video game systems the Odyssey was a poor seller, due in large part to the widespread misconception that it required a Magnavox-brand television to work.

Source: http://www.howtogeek.com/trivia/what-was-the-first-video-game-console-called/

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Study uncovers enzyme's double life, critical role in cancer blood supply

Study uncovers enzyme's double life, critical role in cancer blood supply [ Back to EurekAlert! ] Public release date: 4-Mar-2013
[ | E-mail | Share Share ]

Contact: Jennifer Nachbur
jennifer.nachbur@uvm.edu
802-656-7875
University of Vermont

Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected and critical additional role in cancer metastasis in a study conducted collaboratively in the labs of Karen Lounsbury, Ph.D., University of Vermont professor of pharmacology, and Christopher Francklyn, Ph.D., UVM professor of biochemistry. The group determined that threonyl tRNA synthetase (TARS) leads a "double life," functioning as a critical factor regulating a pathway used by invasive cancers to induce angiogenesis the formation of new blood vessels and a new food supply to sustain their growth.

The teams' research was published online February 21, 2013 in Nature Scientific Reports.

According to Tamara Williams, Ph.D., first author on the study, a lecturer in nursing and postdoctoral fellow in pharmacology at UVM, cancerous tumors quickly outgrow their local blood supply. When they do, the cancer cells send out signals, TARS is secreted, and the angiogenesis process is initiated.

"In our study, we showed that TARS, once thought to only function in the housekeeping role of protein synthesis within cells, 'moonlights' as a secreted signaling agent in the endothelial cells that line vessels, in response to factors commonly produced by cancer cells," says Williams.

The study's in vivo model of angiogenesis was performed using a chick chorioallantoic membrane assay. This experiment utilizes the vascular membrane that surrounds a ten-day-old chicken embryo, which is removed from its shell. Williams and her research teammates placed small pieces of surgical sponges on the surface of the membrane and added compounds, including TARS, to the sponges. The researchers took images of the sponges and surrounding tissues every 24 hours for three days and then analyzed the images to assess the impact of the compounds on local blood vessel development around the sponge. Their test determined whether the compound was angiogenic (creates new blood vessels), had no effect, or was angiostatic (inhibits blood vessel development). Using this assay, the group was able to demonstrate that TARS prompts angiogenesis by increasing the directional movement, or migration, of vessel cells towards the cancer cell signals. The group's research also showed that a potent inhibitor of TARS activity called inhibitor BC194 blocked its induction of angiogenesis.

"The implications of these novel and surprising findings are substantial for the cancer research community and include potential opportunities to develop new, early, and sensitive diagnostics," Williams says.

"Commercially, compounds that reduce TARS could be used to stop angiogenesis in cancer, compounds that increase TARS could promote angiogenesis, and a laboratory blood test for TARS could serve as a diagnostic for progression in certain cancers," says Kerry Swift, M.S., technology licensing officer in the UVM Office of Technology Commercialization.

Williams adds that the anti-angiogenic activity of the potent inhibitor of TARS paves the way for new therapeutics to block tumor growth and metastasis by stopping TARS-induced angiogenesis.

"These types of therapeutics could be used in combination with other treatments that target and kill cancer cells as part of a personalized cancer medicine approach to treat patients with greater success," she says.

On April 22, 2013, Francklyn will present a poster session on this research, titled "Mode of Action of Bioactive Natural Products," at the annual American Society for Biochemistry and Molecular Biology meeting in Boston, Mass. Lounsbury will present the project at the American Association for Cancer Research meeting, which takes place April 6 to 10, 2013 in Washington, D.C.

###


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study uncovers enzyme's double life, critical role in cancer blood supply [ Back to EurekAlert! ] Public release date: 4-Mar-2013
[ | E-mail | Share Share ]

Contact: Jennifer Nachbur
jennifer.nachbur@uvm.edu
802-656-7875
University of Vermont

Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected and critical additional role in cancer metastasis in a study conducted collaboratively in the labs of Karen Lounsbury, Ph.D., University of Vermont professor of pharmacology, and Christopher Francklyn, Ph.D., UVM professor of biochemistry. The group determined that threonyl tRNA synthetase (TARS) leads a "double life," functioning as a critical factor regulating a pathway used by invasive cancers to induce angiogenesis the formation of new blood vessels and a new food supply to sustain their growth.

The teams' research was published online February 21, 2013 in Nature Scientific Reports.

According to Tamara Williams, Ph.D., first author on the study, a lecturer in nursing and postdoctoral fellow in pharmacology at UVM, cancerous tumors quickly outgrow their local blood supply. When they do, the cancer cells send out signals, TARS is secreted, and the angiogenesis process is initiated.

"In our study, we showed that TARS, once thought to only function in the housekeeping role of protein synthesis within cells, 'moonlights' as a secreted signaling agent in the endothelial cells that line vessels, in response to factors commonly produced by cancer cells," says Williams.

The study's in vivo model of angiogenesis was performed using a chick chorioallantoic membrane assay. This experiment utilizes the vascular membrane that surrounds a ten-day-old chicken embryo, which is removed from its shell. Williams and her research teammates placed small pieces of surgical sponges on the surface of the membrane and added compounds, including TARS, to the sponges. The researchers took images of the sponges and surrounding tissues every 24 hours for three days and then analyzed the images to assess the impact of the compounds on local blood vessel development around the sponge. Their test determined whether the compound was angiogenic (creates new blood vessels), had no effect, or was angiostatic (inhibits blood vessel development). Using this assay, the group was able to demonstrate that TARS prompts angiogenesis by increasing the directional movement, or migration, of vessel cells towards the cancer cell signals. The group's research also showed that a potent inhibitor of TARS activity called inhibitor BC194 blocked its induction of angiogenesis.

"The implications of these novel and surprising findings are substantial for the cancer research community and include potential opportunities to develop new, early, and sensitive diagnostics," Williams says.

"Commercially, compounds that reduce TARS could be used to stop angiogenesis in cancer, compounds that increase TARS could promote angiogenesis, and a laboratory blood test for TARS could serve as a diagnostic for progression in certain cancers," says Kerry Swift, M.S., technology licensing officer in the UVM Office of Technology Commercialization.

Williams adds that the anti-angiogenic activity of the potent inhibitor of TARS paves the way for new therapeutics to block tumor growth and metastasis by stopping TARS-induced angiogenesis.

"These types of therapeutics could be used in combination with other treatments that target and kill cancer cells as part of a personalized cancer medicine approach to treat patients with greater success," she says.

On April 22, 2013, Francklyn will present a poster session on this research, titled "Mode of Action of Bioactive Natural Products," at the annual American Society for Biochemistry and Molecular Biology meeting in Boston, Mass. Lounsbury will present the project at the American Association for Cancer Research meeting, which takes place April 6 to 10, 2013 in Washington, D.C.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/uov-sue030413.php

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3 Last Minute Survival Scenarios ? Just Wondering ? Alternative ...

survival-425
by SurvivingSurvivalism.com

Contributor

We know that waiting till the last second is not a good idea, but for some it is the only option. So we have taken three possible average scenarios and broken them down for you. All scenarios will include a family of 4 ? Mom, Dad and two kids under high school age ? living in the suburbs of a megaplex city?

Scenario #1

You have a few cases of water
You have some freeze-dried storage food, maybe a 30 day supply.
You have some sleeping bags and some basic camping supplies.
You have a general idea of the area to which you want to go.
You think maybe something might happen in which case you could need to get your family out of the city.
All supplies are in the garage, ready to load into your minivan should the need arise.

You live in a suburban area of a mexaplex city ? first and foremost, where the hell are you going to go? If you are starting out with only a general idea of where to go, you are planning to fail. Knowing exactly where you are going and a little preparation are very much in order. Even if your plan is to squat on BLM land, National Forest Service land or private land, just having a general idea of where you are going is dangerous. You, see, in your suburb of a megaplex area, how many other people have the same general idea? Of those of like mind, most likely that?s a very high percentage. So have something better than a general idea. Know exactly where you are going and if it?s remote enough, you can hide supplies (not what you must have for survival, but that which you would like to have with you there) in the trees. You just need a cammo cargo net and some rope. Hoist it high into a tree, hidden by the foliage.

Here is an idea I?ve been discussing with people lately. Call it ?Free Advice?: If you have no where to go then the National Forrest my be your best bet. There are several very remote FREE National Forrest camp grounds, (http://www.forestcamping.com/dow/list/nflist.htm) that you can take advantage of. There is one around here (20 miles away) that is very remote and almost no one comes around unless its elk season (Sept. thru Dec.). So before you decide on a campground, check out what dates are the hunting season. Some National Forrest campgrounds have water, some have toilet dumps, most have toilets, some have showers? I have even seen a laundrette at one, and almost no one ever using it. The occasional park ranger will pass by. The Free campground space can by used for 14 consecutive days at a time. Some park rangers interpret this to mean that you must leave the park others interpret it that you have to move to another space in the same campground every 14 days. Either way, if you had to leave the park for one day, only to return the next day, that works, too.

Next to consider is, what would prompt your leaving? Most everyone completely ignores this one because they believe that when the time comes, they?ll ?just know?. What is needed is a clear-cut definition of what event would prompt your bugging out. Even if you jump the gun and get to your survival location too soon, you can always go back to suburbia if you feel the coast is still clear. Some possible guidelines would be: war in Syria or Iran, a banking holiday, if you see military troops in your town setting up check points.

Back in the day there was an old hippie bumper sticker that said, ?The Revolution Will Not Be Televised?. It is also true that CNNFOXABCNBCCBSMSNBC et al will NOT have a news flash that says ?Marshall law will be declared in 30 minutes, so if you?re going to boogie, do it now!? Just remember, if you wait until there is clear unambiguous proof that it?s time to go, you just might find yourself in a traffic jam and no further.

For transportation, a minivan is not going to get you any place safe enough. Consider getting something more robust, such as an older pick up truck (pre-95 is best ? simple electronics, less susceptible to EMP and solar flares) with an extend-a-cab or club-cab for the kids. The RV market has collapsed. Prices have never been lower on used RVs of all types.

With a pickup truck you could get a cab-over camper quite inexpensively. These slip into the cargo area of a pick up. Most sleep 4 or more, have a toilet, shower, water storage tank, oven, range, sink, dining area, a closet and cabinet space. With the economy the way it is, watching craigslist you will find great bargains. Most people are paying in the neighborhood of $500 for an older but still serviceable cab-over camper. If a pick up truck is just not something you can do, then you may want to consider a Coleman-type pop-up camper, which can be towed behind even some compact cars with ease (also about $500 on craigslist). You can use either type of camper to store everything you will need to take with you to your bug-out location, and you?ll be able to just hook up and go when it?s time, no need to think about what to bring. It?s the ultimate ?bug-out-bag?. You can have hundreds of pounds of food and water and supplies in it, without having to crowd the supplies and the family into the minivan.

If the only water you have is a couple of cases, that won?t do it. A case of water is about 2-1/2 gallons of water on average. How many cases can you carry? If you have a cab-over or pop-up camper, both have a fresh water tank to store in the area of 150-200 gallons of water. Check and see if the place you have chosen for your bug-out has any access to water ? lake, pond, stream, river, pump, well, etc. The average person, under Spartan conditions, can just get by on one gallon per day ? 2 quarts to drink and a couple of quarts for cooking and hygiene. Consider the water you?ll need if your food is dehydrated or freeze-dried! So for 4 of you, with a 200 gallon water tank, you would have enough for about 50 days.

If all you have is freeze-dried or dehydrated items for food, you will want to have some items to supplement that, so that you don?t experience appetite fatigue. We would suggest some of the following be added to your supplies for long-term evacuation:
Cocoa Powder
Sugar
Coffee/Tea
Cooking Oil
Flour
Popcorn
Spices
Dried Fruits
Nuts
Jerky
Baking Soda
Vinegar
Molasses

Plus any family favorites, just to break the monotony.

Also, throw into your packing some board games, deck of cards, books, etc., toilet paper and RV toilet sanitizer (blue stuff). If you have extra jeans, socks, shirts, sneakers, shoes/boots ? the clothing you bring can be used outdoors with ease ? as well as toiletries should also be packed. Don?t forget to include a first aid kit. For some of you it will be a military medic/field surgical kit, for others it will be some antiseptic, gauze and tape, depending on your skill level.

Scenario #2

You (and your family) are going to stay in your suburban home.
You have 6 cases of water
You have 6 cases of Dinty Moore Beef Stew and a few miscellaneous canned goods.
You have a shotgun
You don?t want to tell your wife and kids what may be coming up in the near future because it will rock their world. Besides, ?they?ll think I?m nuts.?

In this scenario, there is no need to have a bug-out time definition. But you still need to know what to look for so that you know when to hunker down. So, again, some pre-defined conditions bear strong consideration. What to do, when such and such a thing happens, including a rendezvous place for children to meet you for picking up.

Food will be your biggest concern. Let?s first deal with the ?having?. You?ll need to have food. Basically, nothing different than the previous scenario, although not having to consider transportation, you can store more of it. More importantly, you?ll need to be covert. Being in the suburbs means being around lots of people. Lots of hungry people. The smell of cooking can attract predators ? of all kinds: hungry neighborhood dogs and cats going feral, not to mention your neighbors, themselves, who undoubtedly are hungry. The smell of your cooking anything is going to bring people either knocking on or breaking down your door. What would you do if your kids hadn?t eaten in a week and you smelled food?

Cooking hot food in the suburban environment could garner you a lot of negative attention. For these reasons, ready to eat foods (jerky, dried fruits and vegetables, cookies and crackers) are most desirable. For some of you that might be military MREs. We don?t recommend them as a steady diet ? too much GMO and MSG to name a few ? but in this case they may be useful against hunger while maintaining a low profile.

The power that pumps water to your house may well be disabled. That means that you will not have water coming from your faucet, nor to your toilet for flushing. The -Mart stores sell 5 gallon water bottles (like those used in water coolers) for about $5 each. Get yourself as many as you can, fill them and cover them up where you have your storage items. Refer to the above scenario for daily requirements. Also, fill all your sinks and bathtubs with water while you still have power. Place a garbage bag over the sinks and bathtubs to keep the dust out of the water. Often times forgotten, your water heater has a spigot at the bottom of it, from which you can access the water in there as well ? usually anywhere from 20-40 gallons of additional, usable water.

Some rules about toilet water usage? ?If it?s yellow, let it mellow. If it?s brown, flush it down.? Save the water from washing up (gray water) to use ? as little as possible ? to do the flushing. Pour it into the bowl until the ?brown goes down?. If you want to pour your gray water into your toilet tank, add rocks (too large to get into the flapper hole) or bricks into the tank so that they take up some of the unnecessary water space.

Now, for these scenarios, here is a lesson in ?How Not to Be Seen? (with a tip of the hat to Monty Python). For evacuation scenarios, if you are in a very secluded part of say, the National Forest or private land, it?s a safe bet that if you encounter other people who are not part of your group, you will be encountering trouble. So my advice would be, ?if people move in, move out? and choose another camping sight.

Avoid having large, smoky fires that would attract others. Do most of your fireside cooking during the day and avoid night time fires completely. Also, avoid loud talking, loud music, etc. Don?t think that because you can?t see anyone around you, it?s okay to play your Lead Zeppelin CDs at 800 decibels and no one would notice. You would be surprised how far sound travels in the wilderness, without car noises, people noises, etc., drowning it out.

For Suburban How not to be seen, use no night time lights, even if you have plenty of candles and flashlights. If you do need to illuminate something, do it discretely and for a short time, preferably in a room that has few windows. It?s a good idea to put heavy drapes on your windows also, as long as there are no gaps. Avoid going outside and therefore being noticed. If you have a garage, put your car into it. A car parked outside lets others know there are people inside ? not what you want to do. The car battery can be used as a 12 volt power source if needed, and you can hook up a 110 AC power inverter to use as a house current power source.

?I don?t want to tell the wife and kids what may be coming up in the future because I don?t want to shake their world.? Better to have them prepared than having to follow your instructions while they are in a panic. Like in the movie Knowing, when the little girl?s mother panics, grabs the kids and drives madly toward a cave she knows (so does everyone else), it?s not a good situation. It doesn?t end well. Even if your family thinks you are a tin-foil-hat-wearing loon, if you have at least told them in advance what the trigger point would be, when that point arrives it will be that much less of a shock and they will be apt to be much more on board when the time comes. At some point they?ll have to face it anyway. Better they be prepared than blissfully ignorant until that point.

Scenario #3

You (and your family) are already living at your survival retreat.
You are off the grid, self-sufficient and lovin? the life!
When TSHTF, it will just be another day.

Way to go!

From the authors of Surviving Survivalism ? How to Avoid Survivalism Culture Shock, available at survivingsurvivalism.com

+++

ZenGardner.com

Source: http://www.zengardner.com/3-last-minute-survival-scenarios/

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Sunday, March 3, 2013

Saving Pets ? Blog Archive ? Lost Dogs Home Petfest 2013

03
Mar

When you treat the pet loving public like the enemy, and defend high kill rates in the face of alternatives, you put yourself at odds with the very community you are meant to be serving.

You may be able to dodge and dive, and threaten, and send in the?lawyers and delete comments and ban and try and discredit, but once the community start realising that their experience wasn?t happening in isolation ? that other people have seen healthy pets be killed, other rescues have been denied access to save death row pets, that other people have had their pets ?oopsie? killed? then a ripple that goes out over your community that can never been undone.

Today is the Lost Dogs Home Pet Fest protest ? the very community who loves pets, and would be the greatest champions of a life-saving shelter, the most devoted volunteers and the biggest financial contributors ? are instead pooling their resources into protesting the indefensible 55% kill rate for unclaimed dogs, 80%+ kill rate for unclaimed cats.

This is a live thread for the day.

Banners

Banners from?Bendigo Animal Welfare & Community Services

Banners_2Banners (credit MD)

Banner-SH

Banner (credit SH)

Banners_2 - AL

Banner (credit AL)

Protest_1

Protest (credit MJ)

Protest_2

Protest (credit MJ)

Balloons

(credit KB)

Protest_3

Protesters_2

(credit KN)

Protesters

(credit GW)

Screen Shot 2013-03-03 at 8.21.52 AM

Dogs for adoption (on the biggest day of the year)

Protest-DR(credit DR)

Protest-AS

(credit AS)

Protest-AS_2

(Credit AS)

Protest-RM

(credit RM)

Dog(credit DR)

Protest_4

(credit AG)

See also:

A friend to pets? A review of policies and procedures of Melbourne?s Lost Dogs Home

A friend to pets? A review of policies and procedures of Melbourne?s Lost Dogs Home

The rally the pet lovers of Melbourne have been waiting for

Celebrating 100 years of the Lost Dogs Home

Source: http://www.savingpets.com.au/2013/03/lost-dogs-home-petfest-2013/

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